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dc.contributor.advisorGaitán Ibarra, Ricardo
dc.contributor.authorDuran Lengua, Marlene
dc.date.accessioned2023-01-22T16:54:38Z
dc.date.available2023-01-22T16:54:38Z
dc.date.issued2005
dc.identifier.urihttps://hdl.handle.net/11227/15918
dc.identifier.urihttp://dx.doi.org/10.57799/11227/1308
dc.description.abstractDesde tiempos muy remotos los productos naturales han sido una importantefuente de fármacos, de hecho existen investigaciones de un gran númerodeestos productos que actualmente son usados en la práctica médica (Amador y col., 2003), entre ellos los productos marinos ocupan en la actualidadunimportante sitio como fuente promisoria de agentes terapéuticos. El ecosistema marino representa el 95 % de la biosfera, abarcando unagranvariedad de organismos productores de diversos metabolitos con actividadbiológica que han sido usados ampliamente con gran eficacia y especificidaden el tratamiento de múltiples enfermedades que afectan al hombre (Meyer yLehmann 2000; Burkhard., 2003). Los filum más destacados en cuantoalaproducción de metabolitos secundarios con actividad biológica comprobadason los Poríferos (esponjas) y los Briozoos (zooplancton). En el CaribeyPacífico colombiano existe una gran biodiversidad específica de organismosmarinos ricos en sustancias bioactivas En Colombia existen tres grupos dedicados a la investigación en productosmarinos naturales, ubicados en las Universidades Nacional de Colombia, (Bogotá), Universidad de Antioquia y Universidad de Cartagena dirigidopor los investigadores Carmenza Duque, Alejandro Martínez y Ricardo Gaitán, respectivamente. De sus investigaciones se ha obtenido el aislamientoe identificación de un número de sustancias antibióticas y citotóxicasdeesponjas marinas del caribe Colombianospa
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dc.language.isospaspa
dc.publisherUniversidad de Cartagenaspa
dc.rightsDerechos reservados - Universidad de Cartagena, 2005spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.titleEfecto de los extractos de la esponja marina xestospongia rosariensis sobre mediadores enzimáticos en el proceso inflamatorio utilizando el modelo del polimorfonuclear neutrófilospa
dc.typeTrabajo de grado - Maestríaspa
dcterms.referencesAdkison, A., Raptis, S., Kelly, D. Pham C. (2002). Dipeptidyl peptidaseActivates Neutrophils–derived Serine proteases and regulates thedeveloment of acute experimental arthritis. J. Clin. Inv. 109(3):363-371.
dcterms.referencesAmador, M.L., Jimeno, J., Paz-Ares, P., Cortes-Funes, H e Hidalgo, M. (2003). Progress in the development and acquisition of anticancer agentsfrom marine sources. Ann. Oncol. 14: 1607–1615
dcterms.referencesAlbizati, K., Holman, D., Faulkner, K., Glaser Jacobs, R. (1987). Luffariellolide, an Antiinflammatpry Sesterterpene from the Marine SpongeLuffariella sp. Experientia. 43: 949- 950.
dcterms.referencesArnhold, J. (2004). Free Radicals–Friends or Foes. Properties, Functions, and secretion of Human Myeloperoxidase. Biochemistry. 69(1): 8-15.
dcterms.referencesBae, Y., Song, Y., Kim, Y., He, R., Ye, R., Kwak, J., Suh, P., Ryu, S. (2003). Differential Activation of Formyl Peptide Receptor Signaling by PeptideLigands. Mol. Pharm. 64(4): 841-847.
dcterms.referencesBanks, R. E., Evans, S. W., Taylor, K. F., Bird, H.A., Whicher, J.T. (1990). Measurement of plasma concentrations of polymorphonuclear elastase- proteinase inhibitor (elastase-alfa 1-antitrypsin) in patients with rheumatoidarthritis: interference by rheumatoid factor. Ann Rheum. Dis. 49: 18-21.
dcterms.referencesBarnes, P. Inhales glucocorticoids for Asthma (1995). N. Eng. J. Med. 332(13): 868-874.
dcterms.referencesBarnes, P., Karin, M. (1997). Nuclear Facto-kB–A Pivotal TranscriptionFactor in Chronic Inflammation Diseases. N. Eng. J. Med. 336(15): 1066- 1072.
dcterms.referencesBingol, F., Sener, B. (1995). A review of terrestrial plants and marineorgeanisms having antiinflammatory activity. Int. J. Pharma. 33(2): 81-97.
dcterms.referencesBorregaard, N., Cowland J. (1997). Granules of the Human Neutrophilicpolymorfonuclaer leukocyte. Blood. 89: 3503-3521.
dcterms.referencesBruce, A., Johnson, A., Lewis, J., Roberts, K. (2002). Molecular Biologyof THE CELL. Fourth edition. Garland Science.
dcterms.referencesBurkhard, H. (2003). Drug from the deep: marine natural product as drugcandidates. DDT. 8(12): 536-544.
dcterms.referencesChen, X., Yang, D., Shen, W., Dong, HF., Wang, J.M., Oppenheim, J.J., Howard MZ. (2000). Characterization of chenodeoxycholic acid asanendogenous antagonist of the G-coupled formyl peptide receptors. Inflamm. Res. 49(12): 744-755.
dcterms.referencesCryer, B., Kimmey, MB. (1998). Gastrointestinal side effects of nonsteroidal antiinflammatory drugs. Am. J. Med. 105(1B): 205- 305.
dcterms.referencesDe Rosa, S., Crispino, A., De Giulio, A., Iodice, C., Benrezzouk, R, TerencioMC., Ferrandiz, ML., Alcaraz, MJ., Paya, M. (1998). Anew cacospongionolide inhibitor of human secretory phospholipase A2 fromtheTyrrhenian sponge Fasciospongia cavernosa and absolute configurationof cacospongionolides. J. Nat. Prod. 61:931-935.
dcterms.referencesDona, M., Dell’Aica, I., Calabrese, F., Benelli, R., Morini, M., Albini, A., yGarbisa S. (2003). Neutrophil Restraint by Green Tea: Inhibitionof Inflammation, Associated Angiogenesis, and Pulmonary Fibrosis. J. Inmunol. 8: 4336-4341.
dcterms.referencesDoring, G. (1994). The role of neutrophil elastase in chronic inflammation. Am. J. Respir. Crit Care. Med. 150: 114-117.
dcterms.referencesDueñas, A., Criollo, W., Miranda, AJ., Piamba, E. (1996). Enfermedadperinatal y viabilidad celular renal postmortem in vitro en el Hospital Universitario del Valle, Cali. Colombia Médica. 3(27): 110-116.
dcterms.referencesDuque, C., Zea, S., De Silvestre, J. (1988). Actividad biológicavs. Composición química del extracto cloroformico de la esponja marinaDidiscus oxeata Rev. Col. Quím. 17(1-2): 39.
dcterms.referencesEndemann, G., Feng, Y., Bryant, J., Hamilton, G.S., Perumattam, J., Mewshaw RE., Liu, DY. (1996). Novel anti-inflammatory compounds prevent CD11b/CD18, alpha M beta 2 (Mac-1)-dependent neutrophil adhesionwithout blocking activation- induced changes in Mac-1. Pharmacol. 276(1): 5-12.
dcterms.referencesEspada, M., Avendaño, C. (2001). Inhibidores EnzimáticosFarmacodinámicos, en Introducción a la Química Farmacéutica. Ed2McGraw Hill. Interamericana de España.
dcterms.referencesEscrig, A., Ubeda, M., L. Ferrandiz, J., Darias, J., Sanchez, M. J., Alcaraz., M. Paya. (1997). Variabilin: A dual Inhibitors of Human Secretory andCytosolic Phospholipase A2 With Anti-inflammatory Activity. J. Pharmacol. Exp. Ther. 282(1): 123-131.
dcterms.referencesFalkenstein, E., Tillmann, C., Christ, M., Feuring, M., Wehling, M. (2000). Multiple Actions of Steroid Hormones A Focus on Rapid, Nongenomic Effects. Pharmac. Rev. 52(4): 513-556.
dcterms.referencesFries, J.T. (1996). An understanding of NSAID-related adverse events: Thecontribution of longitudinal data. Scand. J. Rheum. 25(S102): 3-8.
dcterms.referencesFu, J., Masferrer, J., Seibert, K. (1990). The induction and supresiónof prostaglandin H2 syntase (ciclooxigenase) in human monocyte J. Clin. Invest. 86: 1375- 1379.
dcterms.referencesFu, X., Schmitz, F.J., Kelly-Borges, M., McCready, T.L., Holmes, CFB. (1998) Clavosines A-C from the marine sponge Myriastra clavosa: Potent cytotoxinsand inhibitors of protein phosphatases 1 and 2A. J. Org. Chem. 63:7957- 7963.
dcterms.referencesGarcía, L., Pereira, N., Flores, R. (1998). Enzimas generadoras de especiesreactivas del Oxigeno: Mieloperoxidasa. Rev. Cubana. Invest. Biomed. 17(3): 190-7.
dcterms.referencesGonzalez, R., Poza, P., Vives,R. (2002). Antiinflamatorios inhibidoresselectivos de ciclooxigenasa 2 (COX 2). Alergol. Inmunol. Clin. 17: 247-254.
dcterms.referencesHiemstra, P.S. (2002). Novel roles of protease inhibitors in infectionandinflammation. Biochem. Soc. Trans. 30(2): 116-119.
dcterms.referencesHunt, R. (2002). Microbiology and Immunology on line. University of SouthCarolina 1: 8-10.
dcterms.references Henson, Zanolari, B., Scharwarzman, N A., Hong, S R. (1978). Intracelular Control of Human Neutrphil secretion. IC5a-induced Stimulus-SpecificDesensitization and the Effects of Cytochalasin B. J. Inmunol. 121: 851-855.
dcterms.referencesJaszewesky, R. (1990). Frequency of Gastroduodenal lesion in asymptomaticpatients of chronis aspirin or nonsteroidal antiinflamatory drugs. J. Clin. Gastroent. 12: 10-13.
dcterms.referencesJolivalt, C., Leininger-Muller, B., Drozdz, R., Naskalski, J.W., Siest, G. (1996). Apolipoprotein E is highly susceptible to oxidation by mieloperoxidaseanenzime present in the brain. Neurosci. Lett. 210: 61-64.
dcterms.referencesJaovisidha, P., Peeples, Mark., Brees, A., Carpenter, R., Moy, J. (1999). Respiratory Syncytial Virus Stimulates Neutrophil DegranulationandChemokine Release. J. Immunol. 163: 2816–2820.
dcterms.referencesJohansson, S. (2001). Studies on Cytotoxic and Neutrophil ChellengingPolypeptides and Cardiac Glycosides of Plant Origin ComprehensiveSummaries of Upsala. Dissertations from the Faculty of Pharmacy. 255. 1- 74.
dcterms.referencesJohansson, S., Goransson,U., Luijendljk, T., Barklund, A., Claeson, P., Bohlin, L. (2002). Neutrophil Multitarget Functión Biassay to Detect Antiinflamatory Natural Products. J. Nat. Product. 65(1): 35-41
dcterms.referencesKargman, S., Charleson, S., Cartwright, M., Frank, J., Riendeau D,Mancini J. (1996). Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts. Gastroenterology. 111: 445–454.
dcterms.referencesKang K, Bae J, Kim M W, Dae-Heui, L., Cho, U., Myung, L., Mu-SangL, Nam S, Kuettner, K., and Schwuart, D E. (2000). Molecular Characteristicsof the inhibition of human neutrophils elastase by nonesteroidal antiinflammatory drugs. Korean. J. Pharmacol. 32(3): 425-431
dcterms.referencesKernan, M., Faulkner, D., Parkanyi, L., Clardy, J., Carvalho, M., y Jacobs, R. (1989). Lufarielollide, a novel anti-inflammatory terpene fromthe spongeLufarriella sp. Experientia. 45: 388-390.
dcterms.referencesKobayashi, M., Miyamoto, Y., Aoki, S.,Murakami, N., Kitagawa, I., In, I., yIshida, T. (1998). Isomerizatión of Dimeric 2,9-Disubstitued1- oxaquinolizidine Alkaloids and structural revision of Aranguspongines BandE, Isolated from A marine Sponge of Xestospongia sp. Heterocycles. 47(1): 195-203.
dcterms.referencesKimura, J., Ishizuka, E., Nakao, Y., Yoshida, WY. Scheuer, P.J., Borges, M. (1998). Isolation of 1-Methylherbipoline Salts of Halisulfate-1 and of Suvanine as Serine Protease Inhibitors from a Marine Sponge, Coscinodermamathewsi. J. Nat. Prod. 61: 248-250.
dcterms.referencesLe, Y., Gong, W., Tiffany, H.L., Tumanov, A., Nedospasov, S., Shen, W., Dunlop, N.M., Gao, JL., Murphy, PM., Oppenheim, JJ., Wang, JM. (2001a) Amyloid (beta) activates a G-protein-coupled chemoattractant receptor, FPRlike-1. J. Neuro. Sci. 123(42):1–5.
dcterms.referencesLe, Y., Oppenheim, J.J and Wang, JM. (2001b). Pleiotropic roles of formyl peptide receptors. Cytok. Growth. Fact. Rev. 12: 91–105.
dcterms.referencesLe, Y., Iribarren, P., Zhou,Y., Gong, W., Hu, J., Zhang, X., Wang J. (2004). Silencing the Formylpeptide Receptor FPR by Short-Interfering RNAMol. Pharmacol. 66(4): 1022–1028.
dcterms.referencesLehr, H.A., Arfors, KE. (1994). Mechanisms of tissue damage by leukocytes. Curr. Opin. Hematol. 1:92-99.
dcterms.referencesLuster, A. (1998) Chemokines—Chemotactic Cytokines That MediateInflammation. N. Eng. J. Med. 338 (7): 436-445
dcterms.referencesMeyer, A., Lehmann, VK. (2000). Marine pharmacology. The Pharmacologist. 42: 62-69.
dcterms.referencesMeyer, A., Jacobson, P., Fenical, W., Jacobs, R., Glaser, K. (1998). Pharmacological Characterization of Seudopterosins: Novel antiimflamatotynaturals Products isolated from the Caribbean Soft Coral, Pseudopterogorgiaelisabethae. Lif. Sci. 62(26): 401-407.
dcterms.referencesMiyaoka, H., Shimura, M., Kimura, H., Yamada, Y. (1998). Antimalarial activity of kalihinol A and new relative diterpenoids from the okinawan sponge, Acanthella sp. Tetrahedron. 54: 13467-13474.
dcterms.referencesMcConnell OL., Longley RE., Koehn FE. (1994). The Discovery of Natural Products with Therapeutic Potential. Biotechnology. 26: 109-147.
dcterms.referencesMunrro, M., Blunt, J., Dumdei, E., Hickford, S., Lill, R., Li, SH., Battershill, C., Duckworth, A. (1999). The discovery and development of marine compoundswith pharmaceutical potential. J. Biotech. 70: 15- 25
dcterms.referencesNick, J., Avdi, J., Gerwins, P., Whorthen, G. (1996). Activation of ap38Mitogen –activated protein kinasa in human neutrophils by lipopolisacarideJ. Immunol. 156: 4867-4875
dcterms.referencesNakao, Y., Oku, N., Matsunaga, S., Fusetani, N. (1998). CyclotheonamidesE2 and E3, new potent serineprotease inhibitors from the marine spongeof the genus Theonella. J. Nat. Prod. 61: 667-670.
dcterms.referencesNorthcote, P., Andersen, R. (1988). Xestenone, a new Bicyclic C19Terpenoid from the Marine Sponge Xestospongia Vanilla. TetrahedronLetters. 29(35): 4357-4360
dcterms.referencesOlivero, V. J. (1999). Activation of Phospholipase A2. By Polyclorinatedbiphenyls (PCBs) and other clorinated copounds. Thesis Ph D.
dcterms.referencesO’Keefe, B.R., Erim, T., Beutler, J.A., Cardellina, J.H., Gulakowski, R.J., Krepps, B.L., McMahon, J.B., Sowder, R.C., Johnson, D.G., Buckheit, RW., Halliday, S., Boyd, M.R. (1998). Isolation and characterization of adociavirin, a novel HIV-inhibitory protein from the sponge Adocia sp. Lett. 431: 85-90
dcterms.referencesPettit, R.K., McAllister, S.C., Pettit, G.R., Herald, C.L., Johnson, JM., Cichacz, ZA. (1998). A broad-spectrum antifungal from the marine sponge Hyrtioserecta. Int. J. Antimic. Agents. 9:147-152.
dcterms.referencesPérez, J., Mayz, J., Alfonso, C., Gómez, J., Nirchio, M., Manzi, L. (2004). Tienen Las Plantas Mas Compuestos Bioactivos que los Animales. Tecnociencia. 6(1): 153-169.
dcterms.referencesPinheiro, M., Calixto, J. B. (2002) Effect of the selective COX 2 inhibitors, Celecoxib and rofecoxib in rat acute models of inflammation. Inflamm. Res. 51: 603-610.
dcterms.referencesPodrez, E.A., Schmitt, D., Of, H.F., Hazen, S.L. (1999). Myeloperoxidase- generated reactive nitrogen species convert LDL into an atherogenic forminvitro J. Clin. Invest. 103: 1547-1560.
dcterms.referencesRamos, F. (2001). Epidemiología y manejo de los efectos adversos delosantiinflamatorios no esteroides a nivel gastroduodenal. Revista medicadel hospital general de México. 64(1): S20-S27.
dcterms.referencesRees, D., Brain, J., Wohl, ME., Humes, J., Mumford, R. (1997) Inhibitionof Neutrophil elastasa in CF sputum by L-658,758. J. Pharmacol. Exp. Ther. 283(3): 1201- 1206.
dcterms.referencesRoberts, L.J., Morrow, J. (2002). Analgésicos Antipiréticos Antiinflamatorios, y fármacos antigotosos. En Bases Farmacológicas de la TerapéuticadeGoodman y Gilman. Eds. Goodman, A., Hardman, J., Limbird, L., Ed 10, McGraw Hill. Tomo 1.
dcterms.referencesRomo, D., Rzasa, RM., Shea, HA. Park, K., Langenhan, JM., Sun, L., Akhiezer, A., Liu, JO. (1998). Total synthesis and immunosuppressive activityof (-)-pateamine A and related compounds: implementation of a betalactumbased macrocyclization. J. Am. Chem. Soc. 120: 12237-12254.
dcterms.referencesRojas, W., y Cano, L. (2001). Inflamación Inmunológia ed 12. CIB.
dcterms.referencesRupperts., Barnes. (2000). Zoología de los invertebrados. Sexta ediciónMcGraw-Hill.
dcterms.referencesSaag, K.G., (1999). Epidemiology of Glucocorticoide-Induced OsteoporosisConcepts and controversies. J. Clin. Reumatol. 5: 53-59.
dcterms.referencesSayed, K A., Kelly, M., Kara, UAK. Ang, K H., Katsuyama, D., Khan, A., Hatman, MT. (2001). New Manzamine Alkaloids with Potent activity against infectious Disease. J. Am. Soc. 123: 1804-1808.
dcterms.referencesSchoen, R., Vender, R. (1989). Mechanisms of nonsteroidal antiinflammatory drug-induced gastric damage. Am. J. Med. 86: 449-458.
dcterms.referencesSugidachi, A., Ogawa, T., Asai, F., Saito, S., Ozaki H, Fusetani, N., Karaki, H., Koike, H. (1998). Inhibition of rat platelet aggregation by mycalolide-B, anovel inhibitor of actin polymerization with a different mechanismof actionfrom cytochalasin-D. Throm. Haemos. 79: 614-619.
dcterms.referencesShapiro, S. D. (2002). Proteinases in Chronic obstructive pulmonary Disease. Biochem. Soc. Trans. 30(2): 98-102.
dcterms.referencesShu, Y., Yoshida.,Kelly-Borges, M., Scheuer, P. (1998). Noelaquinone, ANew Hexacyclic Triazine Quinone from an Indonesian Xestospongiasp. Heterocycles. 49: 355-360.
dcterms.referencesTravis, H W., Bjornsen, J., Elzi, D., Smith, S. (2002). Endothelial apoptosis: could it have a role in the pathogenesis and treatment of disease Chest. 117: 841-854.
dcterms.referencesTravis, J. (1988) Structure, Function, and Control of Neutrophil proteinases. Am. J. Med. 84(6A): 37-42.
dcterms.referencesTremacoldi, C., Pascholati, S. (2002). Detection of tripsin Inhibitor in seedof Eucalyptus urophilla and its influence on the in vitro growth of thefungi Pisolithus tinctorius and Rhizoctonia solani. Brazilian. J. Microbiol. 33: 281- 286.
dcterms.referencesTuominen, M., Bohlin, L., Rolfsen, W. (1992). Effects of Calaguala andanActive principle, Adenosine, on Platelet activating factor. Plant. med. 58: 306- 310
dcterms.referencesVieira O, Botelho R, Grinstein, S. (2002). Fagosoma maturation: AginGracefully. Review article. J. Biochem. 366: 689- 704
dcterms.referencesVilladiego, G., Henrriquez, R. (2003). Acción Antiinflamatoria de los extractosde las Esponjas Marinas Xestospongia rosariensis y Xestospongia proximaen Edema Plantar de Rata Inducido por Carragenina. Tesis de gradoparaoptar al titulo de Q.F. Facultad de Ciencias Química y FarmacéuticasUniversidad de Cartagena.
dcterms.referencesWinter, C. A., Risley, E. A., and Nuss, G. W. (1962). Carrageenan inducedoedema in hind paw of the rats as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Bio Med. 111: 544-547.
dcterms.referencesXingxing, Z., Yazdanbakhsh, M., Jiang, H., Kanost, M., Maizels, R. (1999). Anovel serpins Expressed by Blood – Borne Microfilariae of tha ParasiticNematode Brugia malayi inhibits Human Neutrophil serine Proteinases. Blood. 94(4): 1418-1428.
dcterms.referencesYa-Ching, S., Kuang, L., Lo, Yao- Haur, K., Rupat C. (2002). PolycyclicQuinones and Hidroquinones, antitumor constituents from Taiwanese marineSponge Zestospongia sp. Chinese. Pharmacol. J. 54: 207- 213.
dcterms.referencesWagner, J., Roth, R. (2000). Neutrophil Migration Mechanisms, withanEmphasis on the Pulmonary Vasculature. Pharmacol. Rev. 52: 349-374
dcterms.referencesWalzog, B., Gaehtgens, P. (2000). Adhesion Molecules: The Path to aNewUnderstanding of acute inflammation. N. Physiol. Sci. 15: 107-113.
dcterms.referencesWalpole, R.E., Myers, R.H., Myer, S.L., Ye, K. (2001). Probability andStatistics for Engineers and Scientists, 7th ed., Prentice Hall.
dcterms.referencesWinterbourn, C., Vissers, C.M., Kettle, A.P. (2000). Myeloperoxidase Current. Opinion. In. Hematol. 7: 53–58.
dcterms.referencesWolfe, M., Lichtenstein, DR., Singh, G. (1999). Gastrointestinal toxicityof nonsteroidal antiinflammatory drugs. N. Eng. J. Med. 340: 1888-1899.
dcterms.referencesWilliams, C., DuBois, R. (1996). Prostaglandin endoperóxido synthaseWhytwo isoformas. Am. J. Physiol. 270: 393- 400.
dcterms.referencesZhang, R., Brennand, M., Cheng, Z., McPherson, C., Schmitt, D., Molenda, CH., Hasen, S. (2002). Myeloperoxidase Functions as a major Enzimaticcatalyst for Initiation of Lipid Peroxidation at sites of Inflammation. J. Biol. Chem. 227(48): 46116-46122.
dcterms.referencesZhang, W., Xue, S., Zhao, Q., Zhang, X., Li, J., Jin, M., Yu, X., Yuan, Q. (2003) Biopotentials of marine sponge from China oceans: past and future. Biomol. Engineer. 20: 413-419.
dcterms.referencesZea, S. (1987). Esponjas del caribe colombiano Instituto de investigacionesmarinas y costeras INVEMAR. Editorial catalogo cientifico. Ed 1.
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Farmacologíaspa
dc.publisher.facultyFacultad de Medicinaspa
dc.publisher.placeCartagena de Indiasspa
dc.publisher.programMaestría en Farmacologíaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.subject.armarcMedicamentos
dc.subject.armarcQuímica vegetal
dc.subject.armarcBotánica química
dc.subject.armarcPoríferos
dc.subject.armarcEsponjas (Zoología)
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