| dc.contributor.advisor | Gómez Camargo, Doris Esther | |
| dc.contributor.author | Valle Molinares, Roger Humberto | |
| dc.date.accessioned | 2022-07-28T18:28:12Z | |
| dc.date.available | 2022-07-28T18:28:12Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | P. aeruginosa es un patógeno oportunista que representa un problema de salud pública, siendo uno de microorganismos frecuentemente aislado en casos de infecciones asociadas a la atención en salud y que expresa resistencia a la mayoría de los antibióticos de uso rutinario. En este trabajo, realizamos un análisis de los perfiles de susceptibilidad, producción de biopelículas y expresión de genes asociados a resistencia antibiótica, de un total de 60 aislados (56 de origen clínico y 4 de origen ambiental). Los resultados obtenidos permitieron realizar una descripción fenotípica y genotípica de la población de P. aeruginosa que circula en la ciudad de Cartagena. La mayoría de los aislamientos mostraron elevados niveles de resistencia (30% MDR, 32% XDR y 15% PDR). Así mismo, se encontró que los marcadores de resistencia blaTEM y blaSHV son los más frecuentes en la población de P. aeruginosa con frecuencias de aparición del 26% y 100% respectivamente. Por otro lado, en este trabajo aportamos evidencia de la sobreexpresión en la biopelícula de los genes blaSHV lo que puede ser de utilidad a la hora es escoger el tratamiento antibiótico más adecuado para el manejo de infecciones crónicas de P. aeruginosa. También, aportamos información preliminar sobre el potencial uso de moléculas de origen natural (extractos crudos de animales marinos) y sintéticos (Tedrahydroquinolinas) en el tratamiento de infecciones de P. aeruginosa. | spa |
| dc.description.degreelevel | Doctorado | spa |
| dc.description.degreename | Doctor(a) en Medicina Tropical | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.identifier.uri | https://hdl.handle.net/11227/15503 | |
| dc.identifier.uri | http://dx.doi.org/10.57799/11227/147 | |
| dc.language.iso | spa | spa |
| dc.publisher | Universidad de Cartagena | spa |
| dc.publisher.faculty | Facultad de Medicina | spa |
| dc.publisher.place | Cartagena de Indias | spa |
| dc.publisher.program | Doctorado en Medicina Tropical | spa |
| dc.rights | Derechos Reservados - Universidad de Cartagena, 2020 | spa |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
| dc.rights.creativecommons | Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) | spa |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | spa |
| dc.subject.armarc | Microorganismos | |
| dc.subject.armarc | Antibióticos - Efectos fisiológicos | |
| dc.subject.armarc | Antibióticos | |
| dc.subject.armarc | Microorganismo - Efecto de los antibióticos | |
| dc.subject.armarc | Bacterias - Fisiología | |
| dc.title | Diversidad genética de Pseudomonas aeruginosa y su relación con la resistencia bacteriana y producción de biopelículas en la ciudad de Cartagena de Indias D.C.T.-Colombia | spa |
| dc.type | Trabajo de grado - Doctorado | spa |
| dc.type.coar | http://purl.org/coar/resource_type/c_db06 | spa |
| dc.type.content | Text | spa |
| dc.type.driver | info:eu-repo/semantics/doctoralThesis | spa |
| dc.type.redcol | https://purl.org/redcol/resource_type/TD | spa |
| dc.type.version | info:eu-repo/semantics/publishedVersion | spa |
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