| dc.contributor.advisor | Yasnot Acosta, María Fernanda | |
| dc.contributor.author | Tovar Acero, Catalina | |
| dc.date.accessioned | 2022-07-28T13:57:31Z | |
| dc.date.available | 2022-07-28T13:57:31Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | En el contexto fisiopatológico de las infecciones mediadas por Plasmodium se ha documentado que la respuesta mediada por citoquinas proinflamatorias o antiinflamatorias contribuyen a la eliminación del parásito; sin embargo, una respuesta inmunológica exacerbada que puede favorecer el desarrollo de cuadros complicados de la enfermedad. En los últimos años ha sido estudiado el papel de las citoquinas en la patogénesis de la malaria, así como su rol como biomarcadores capaces de pronosticar el desarrollo una complicación en pacientes que padecen esta enfermedad. Disponer de un biomarcador con estas características, es un insumo para generar herramientas diagnósticas que permitan de manera temprana dar un mejor enfoque clínico y terapéutico al paciente, por otra parte, es importante generar información que contribuya al conocimiento de la fisiopatología en las infecciones por Plasmodium vivax. Este estudio tuvo como finalidad evaluar del perfil de citoquinas de monocitos, linfocitosTh1 y linfocitos Treg en la malaria complicada por Plasmodium vivax en una zona endémica para la enfermedad en el noreste de Colombia. Se vincularon 156 individuos, conformando tres grupos de estudio, pacientes con malaria complicada, malaria no complicada y controles sanos. La trombocitopenia, la hipoglicemia, la disfunción hepática y renal fueron las complicaciones más frecuentes observadas en la malaria por P. vivax en la población de estudio. La evaluación de las citoquinas derivadas de los monocitos, Th1 y Treg, permitió identificar que la concentración plasmática de IL-6, IL-10 y IFN-γ marca un perfil diferenciador entre pacientes complicados y no complicados, la concentración aumentada de estas citoquinas mostró correlaciones con manifestaciones complicadas como la trombocitopenia severa, hipoglicemia, alteraciones hepáticas y renales. Adicionalmente, IL-6 mostró potencial para pronosticar el desarrollo de complicaciones en pacientes con infección por P. vivax. El TGF-β se postula como una citoquina moduladora de la inflamación en la infección por P. vivax, se encontró una mayor concentración de esta citoquina en el grupo control y en pacientes no complicados; sin embargo, las células Treg parecen estar suprimidas en pacientes complicados favoreciendo un ambiente proinflamatorio de citoquinas como IFN-γ e IL-6, que media las complicaciones observadas en los pacientes. El papel de la IL-10 parece estar asociado al desarrollo de complicaciones en la malaria por P. vivax, fue la citoquina con mayor concentración plasmática en pacientes con malaria complicada, y postulamos que la fuente de esta citoquina en el curso de esta infección proviene de fuentes celulares diferentes a Treg. Este es el primer estudio en Colombia que se realiza comparando grupos de pacientes con malaria vivax con diferentes formas clínicas y evalúa el comportamiento de las citoquinas en el curso de las infecciones, estas aproximaciones generan conocimiento de la inmunopatogénesis de este parásito que puede ser explorado en pronóstico de complicaciones o en blancos terapéuticos. | spa |
| dc.description.degreelevel | Doctorado | spa |
| dc.description.degreename | Doctor(a) en Medicina Tropical | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.identifier.uri | https://hdl.handle.net/11227/15502 | |
| dc.identifier.uri | http://dx.doi.org/10.57799/11227/144 | |
| dc.language.iso | spa | spa |
| dc.publisher | Universidad de Cartagena | spa |
| dc.publisher.faculty | Facultad de Medicina | spa |
| dc.publisher.place | Cartagena de Indias | spa |
| dc.publisher.program | Doctorado en Medicina Tropical | spa |
| dc.rights | Derechos Reservados - Universidad de Cartagena, 2021 | spa |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
| dc.rights.creativecommons | Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) | spa |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | spa |
| dc.subject.armarc | Malaria | |
| dc.subject.armarc | Parásito de la malaria | |
| dc.subject.armarc | Plasmodium | |
| dc.subject.armarc | Malaria - Epidemiologia | |
| dc.title | Evaluación del perfil de citoquinas de monocitos, Th1 y Treg en malaria complicada por Plasmodium vivax | spa |
| dc.type | Trabajo de grado - Doctorado | spa |
| dc.type.coar | http://purl.org/coar/resource_type/c_db06 | spa |
| dc.type.content | Text | spa |
| dc.type.driver | info:eu-repo/semantics/doctoralThesis | spa |
| dc.type.redcol | https://purl.org/redcol/resource_type/TD | spa |
| dc.type.version | info:eu-repo/semantics/publishedVersion | spa |
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