| dc.contributor.advisor | Arroyo Salgado, Bárbara Julia | |
| dc.contributor.author | Gómez Arcila, Verónica | |
| dc.date.accessioned | 2022-03-18T15:11:31Z | |
| dc.date.available | 2022-03-18T15:11:31Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | Las zoonosis emergentes, son enfermedades infecciosas transmitidas por vectores invertebrados, que han cobrado gran importancia y continúan en expansión geodemográfica. Sin embargo, aún es desconocido el impacto de estas entidades en países tropicales como Colombia, donde el número de casos transmitidos por estos vectores se ha pronunciado de forma silente, con identificación de eventos fortuitos que han llegado, incluso, a ser letales. Por lo tanto, el conocimiento y comportamiento de estas entidades juega un papel crucial en la identificación de los casos y diagnóstico temprano a través de metodologías diagnósticas eficaces. Objetivo: Realizar la detección microbiológica y molecular de los patógenos emergentes: Anaplasma spp, Ehrlichia spp y Babesia spp, causantes de zoonosis y su caracterización clínica en pacientes de la ciudad de Cartagena en el año 2015. Métodos: Estudio descriptivo, transversal. Que evaluó las características epidemiológicas, clínicas, microbiológicas y moleculares de los pacientes febriles incluidos en el estudio previo consentimiento informado. Posterior a la toma de muestra sanguínea de los pacientes, el ADN genómico fue extraído, seguido de su cuantificación, valoración de integridad y pureza. La presencia de patógenos (Anaplasma spp., Ehrlichia spp. y Babesia spp.) fue analizada a través de la reacción en cadena de la polimerasa (PCR). Resultados: Fue recolectada la información de 175 pacientes, en quienes fueron identificados los microorganismos: Anaplasma spp. (2,7%) y Babesia spp (1,3%). Al análisis de la especie, dichas muestras, dieron positivas para A. phagocytophilum (1/2) y B. microti (1/1) respectivamente. Respecto a la detección microbiológica, fueron detectadas mórulas típicas en los neutrófilos (5,3%) y trofozoitos en forma anular y piriformes dentro de los eritrocitos (1,3%). Conclusión: este es el primer estudio que utiliza métodos moleculares en el Caribe Colombiano para determinar la presencia de patógenos emergentes Anaplasma spp., Ehrlichia spp. y Babesia spp. en humanos, constatando la prueba de PCR convencional como una herramienta sensible y específica para el diagnóstico y mandatorio ante pacientes con factores de riesgo asociados a zoonosis. | spa |
| dc.description.degreelevel | Maestría | spa |
| dc.description.degreename | Magíster en Microbiología | spa |
| dc.format.extent | 104 hojas | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.identifier.uri | https://hdl.handle.net/11227/14818 | |
| dc.identifier.uri | http://dx.doi.org/10.57799/11227/1365 | |
| dc.language.iso | spa | spa |
| dc.publisher | Universidad de Cartagena | spa |
| dc.publisher.faculty | Facultad de Medicina | spa |
| dc.publisher.place | Cartagena de Indias | spa |
| dc.publisher.program | Maestría en Microbiología | spa |
| dc.rights | Derechos Reservados - Universidad de Cartagena, 2015 | spa |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
| dc.rights.creativecommons | Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) | spa |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | spa |
| dc.subject.armarc | Zoonósis | |
| dc.subject.armarc | Enfermedades zoonóticas | |
| dc.subject.armarc | Enfermedades transmisibles | |
| dc.subject.armarc | Microbiología médica | |
| dc.title | Caracterización microbiológica y molecular de patógenos emergentes: Anaplasma SPP, Babesia SPP y Ehrlichia SPP causantes de antropozoonosis en la ciudad de Cartagena 2015 | spa |
| dc.type | Trabajo de grado - Maestría | spa |
| dc.type.coar | http://purl.org/coar/resource_type/c_bdcc | spa |
| dc.type.content | Text | spa |
| dc.type.driver | info:eu-repo/semantics/masterThesis | spa |
| dc.type.redcol | https://purl.org/redcol/resource_type/TM | spa |
| dc.type.version | info:eu-repo/semantics/publishedVersion | spa |
| dcterms.references | Aguero-Rosenfeld, M.E., 2002. Diagnosis of human granulocytic ehrlichiosis: state of the art. Vector borne and zoonotic diseases 2, 233-239. | |
| dcterms.references | Arraga-Alvarado, C.M., Qurollo, B.A., Parra, O.C., Berrueta, M.A., Hegarty, B.C., Breitschwerdt, E.B., 2014. Case report: Molecular evidence of Anaplasma platys infection in two women from Venezuela. The American journal of tropical medicine and hygiene 91, 1161-1165. | |
| dcterms.references | Bakken, J.S., Aguero-Rosenfeld, M.E., Tilden, R.L., Wormser, G.P., Horowitz, H.W., Raffalli, J.T., Baluch, M., Riddell, D., Walls, J.J., Dumler, J.S., 2001. Serial measurements of hematologic counts during the active phase of human granulocytic ehrlichiosis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 32, 862-870. | |
| dcterms.references | Bakken, J.S., Dumler, J., 2002. Ehrlichia and Anaplasma species (ehrlichiosis). Antimicrobial Therapy and Vaccines. 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins, 875-882. | |
| dcterms.references | Bakken, J.S., Dumler, J.S., 2000. Human granulocytic ehrlichiosis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 31, 554-560 | |
| dcterms.references | Bakken, J.S., Krueth, J., Wilson-Nordskog, C., Tilden, R.L., Asanovich, K., Dumler, J.S., 1996. Clinical and laboratory characteristics of human granulocytic ehrlichiosis. JAMA 275, 199-205. | |
| dcterms.references | Banerjee, R., Anguita, J., Roos, D., Fikrig, E., 2000. Cutting edge: infection by the agent of human granulocytic ehrlichiosis prevents the respiratory burst by down-regulating gp91phox. Journal of immunology 164, 3946-3949. | |
| dcterms.references | Baneth, G., 2014. Tick-borne infections of animals and humans: a common ground. International journal for parasitology. | |
| dcterms.references | Barratt, J.L., Harkness, J., Marriott, D., Ellis, J.T., Stark, D., 2010. Importance of nonenteric protozoan infections in immunocompromised people. Clinical microbiology reviews 23, 795-836. | |
| dcterms.references | Blancou, J., Chomel, B.B., Belotto, A., Meslin, F.X., 2005. Emerging or re- emerging bacterial zoonoses: factors of emergence, surveillance and control. Veterinary research 36, 507-522. | |
| dcterms.references | Bloch, E.M., Lee, T.H., Krause, P.J., Telford, S.R., 3rd, Montalvo, L., Chafets, D., Usmani-Brown, S., Lepore, T.J., Busch, M.P., 2013. Development of a realtime polymerase chain reaction assay for sensitive detection and quantitation of Babesia microti infection. Transfusion 53, 2299-2306. | |
| dcterms.references | Botero, A.H., Muñoz Ramirez, F., Vega Miranda, J., 2014. First case of human monocytic ehrlichiosis reported in Colombia. Infectio 18, 158-161. | |
| dcterms.references | Breitschwerdt, E.B., Hegarty, B.C., Qurollo, B.A., Saito, T.B., Maggi, R.G., Blanton, L.S., Bouyer, D.H., 2014. Intravascular persistence of Anaplasma platys, Ehrlichia chaffeensis, and Ehrlichia ewingii DNA in the blood of a dog and two family members. Parasit Vectors 1, 298. | |
| dcterms.references | Buelvas, F., Alvis, N., Buelvas, I., Miranda, J., Mattar, S., 2008. A high prevalence of antibodies against Bartonella and Babesia microti has been found in villages and urban populations in Cordoba, Colombia. Revista de Salud Pública 10, 168-177 | |
| dcterms.references | Buller, R.S., Arens, M., Hmiel, S.P., Paddock, C.D., Sumner, J.W., Rikhisa, Y., Unver, A., Gaudreault-Keener, M., Manian, F.A., Liddell, A.M., Schmulewitz, N., Storch, G.A., 1999. Ehrlichia ewingii, a newly recognized agent of human ehrlichiosis. The New England journal of medicine 341, 148-155. | |
| dcterms.references | Cabezas-Sánchez, C., 2015. Enfermedades infecciosas emergentesreemergentes y sus determinantes. Revista Peruana de Medicina Experimental y Salud Pública 32. | |
| dcterms.references | Campuzano, M., 2008. ¿ Cómo obtener un extendido de sangre periférica de óptima calidad? Medicina & Laboratorio 14, 125-152. | |
| dcterms.references | Cao, W.C., Gao, Y.M., Zhang, P.H., Zhang, X.T., Dai, Q.H., Dumler, J.S., Fang, L.Q., Yang, H., 2000. Identification of Ehrlichia chaffeensis by nested PCR in ticks from Southern China. Journal of clinical microbiology 38, 2778-2780 | |
| dcterms.references | Carlyon, J.A., Chan, W.T., Galan, J., Roos, D., Fikrig, E., 2002. Repression of rac2 mRNA expression by Anaplasma phagocytophila is essential to the inhibition of superoxide production and bacterial proliferation. Journal of immunology 169, 7009-7018. | |
| dcterms.references | Cunningham, A.A., 2005. A walk on the wild side--emerging wildlife diseases. Bmj 331, 1214-1215. | |
| dcterms.references | Chan, K., Marras, S.A., Parveen, N., 2013. Sensitive multiplex PCR assay to differentiate Lyme spirochetes and emerging pathogens Anaplasma phagocytophilum and Babesia microti. BMC microbiology 13, 295 | |
| dcterms.references | Chapman, A.S., Bakken, J.S., Folk, S.M., Paddock, C.D., Bloch, K.C., Krusell, A., Sexton, D.J., Buckingham, S.C., Marshall, G.S., Storch, G.A., Dasch, G.A., McQuiston, J.H., Swerdlow, D.L., Dumler, S.J., Nicholson, W.L., Walker, D.H., Eremeeva, M.E., Ohl, C.A., Tickborne Rickettsial Diseases Working, G., Cdc, 2006. Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever, ehrlichioses, and anaplasmosis--United States: a practical guide for physicians and other health-care and public health professionals. MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports / Centers for Disease Control 55, 1-27. | |
| dcterms.references | Chen, S.M., Dumler, J.S., Bakken, J.S., Walker, D.H., 1994. Identification of a granulocytotropic Ehrlichia species as the etiologic agent of human disease. Journal of clinical microbiology 32, 589-595. | |
| dcterms.references | Childs, J.E., Paddock, C.D., 2003. The Ascendancy of Amblyomma americanum as a Vector of Pathogens Affecting Humans in The United States*. Annual Review of Entomology 48, 307-337. | |
| dcterms.references | De Tommasi, A.S., Baneth, G., Breitschwerdt, E.B., Stanneck, D., Dantas-Torres, F., Otranto, D., de Caprariis, D., 2014. Anaplasma platys in bone marrow megakaryocytes of young dogs. Journal of clinical microbiology 52, 2231- 2234. | |
| dcterms.references | Demma, L.J., Holman, R.C., McQuiston, J.H., Krebs, J.W., Swerdlow, D.L., 2006. Human monocytic ehrlichiosis and human granulocytic anaplasmosis in the United States, 2001-2002. Ann N Y Acad Sci 1078, 118-119. | |
| dcterms.references | Dong, T., Qu, Z., Zhang, L., 2013. Detection of A. phagocytophilum and E. chaffeensis in patient and mouse blood and ticks by a duplex real-time PCR assay. PloS one 8, e74796. | |
| dcterms.references | Doudier, B., Olano, J., Parola, P., Brouqui, P., 2010. Factors contributing to emergence of Ehrlichia and Anaplasma spp. as human pathogens. Veterinary parasitology 167, 149-154. | |
| dcterms.references | Dumler, J.S., 2005. Anaplasma and Ehrlichia infection. Ann N Y Acad Sci 1063, 361-373. | |
| dcterms.references | Dumler, J.S., Bakken, J.S., 1995. Ehrlichial diseases of humans: emerging tick- borne infections. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20, 1102-1110. | |
| dcterms.references | Dumler, J.S., Barat, N.C., Barat, C.E., Bakken, J.S., 2007a. Human granulocytic anaplasmosis and macrophage activation. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 45, 199- 204. | |
| dcterms.references | Dumler, J.S., Barbet, A.F., Bekker, C.P., Dasch, G.A., Palmer, G.H., Ray, S.C., Rikihisa, Y., Rurangirwa, F.R., 2001. Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and 'HGE agent' as subjective synonyms of Ehrlichia phagocytophila. International journal of systematic and evolutionary microbiology 51, 2145-2165. | |
| dcterms.references | Dumler, J.S., Madigan, J.E., Pusterla, N., Bakken, J.S., 2007b. Ehrlichioses in humans: epidemiology, clinical presentation, diagnosis, and treatment. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 45 Suppl 1, S45-51. | |
| dcterms.references | Dumler, J.S., Madigan, J.E., Pusterla, N., Bakken, J.S., 2007c. Ehrlichioses in humans: epidemiology, clinical presentation, diagnosis, and treatment. Clinical infectious diseases 45, S45-S51. | |
| dcterms.references | Dunning Hotopp, J.C., Lin, M., Madupu, R., Crabtree, J., Angiuoli, S.V., Eisen, J.A., Seshadri, R., Ren, Q., Wu, M., Utterback, T.R., Smith, S., Lewis, M., Khouri, H., Zhang, C., Niu, H., Lin, Q., Ohashi, N., Zhi, N., Nelson, W., Brinkac, L.M., Dodson, R.J., Rosovitz, M.J., Sundaram, J., Daugherty, S.C., Davidsen, T., Durkin, A.S., Gwinn, M., Haft, D.H., Selengut, J.D., Sullivan, S.A., Zafar, N., Zhou, L., Benahmed, F., Forberger, H., Halpin, R., Mulligan, S., Robinson, J., White, O., Rikihisa, Y., Tettelin, H., 2006. Comparative genomics of emerging human ehrlichiosis agents. PLoS genetics 2, e21. | |
| dcterms.references | Estrada-Pena, A., Horak, I.G., Petney, T., 2008. Climate changes and suitability for the ticks Amblyomma hebraeum and Amblyomma variegatum (Ixodidae) in Zimbabwe (1974-1999). Veterinary parasitology 151, 256-267. | |
| dcterms.references | Faccini-Martínez, Á.A., Montenegro-Herrera, C.A., Hidalgo, M., 2015. A propósito del primer caso de ehrlichiosis monocítica humana reportado en Colombia. Infectio 19, 47-48. | |
| dcterms.references | Fichtenbaum, C.J., Peterson, L.R., Weil, G.J., 1993. Ehrlichiosis presenting as a life-threatening illness with features of the toxic shock syndrome. The American journal of medicine 95, 351-357. | |
| dcterms.references | Gestal Otero, J.J., 1997. Enfermedades infecciosas emergentes. Alerta mundial. Respuesta mundial. Revista Española de Salud Pública 71, 225-229 | |
| dcterms.references | Harvey, J.W., 2011. Veterinary hematology: a diagnostic guide and color atlas. Elsevier Health Sciences. | |
| dcterms.references | Hatcher, J.C., Greenberg, P.D., Antique, J., Jimenez-Lucho, V.E., 2001. Severe babesiosis in Long Island: review of 34 cases and their complications. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 32, 1117-1125. | |
| dcterms.references | Herwaldt, B.L., Caccio, S., Gherlinzoni, F., Aspock, H., Slemenda, S.B., Piccaluga, P., Martinelli, G., Edelhofer, R., Hollenstein, U., Poletti, G., Pampiglione, S., Loschenberger, K., Tura, S., Pieniazek, N.J., 2003a. Molecular characterization of a non-Babesia divergens organism causing zoonotic babesiosis in Europe. Emerging infectious diseases 9, 942-948. | |
| dcterms.references | Herwaldt, B.L., McGovern, P.C., Gerwel, M.P., Easton, R.M., MacGregor, R.R., 2003b. Endemic babesiosis in another eastern state: New Jersey. Emerging infectious diseases 9, 184-188. | |
| dcterms.references | Hoberg, E.P., Brooks, D.R., 2015. Evolution in action: climate change, biodiversity dynamics and emerging infectious disease. Philosophical Transactions of the Royal Society of London B: Biological Sciences 370, 20130553. | |
| dcterms.references | Homer, M.J., Aguilar-Delfin, I., Telford, S.R., 3rd, Krause, P.J., Persing, D.H., 2000. Babesiosis. Clinical microbiology reviews 13, 451-469. | |
| dcterms.references | Hong, S.H., Anu, D., Jeong, Y.I., Abmed, D., Cho, S.H., Lee, W.J., Lee, S.E., 2014. Molecular detection and seroprevalence of Babesia microti among stock farmers in Khutul City, Selenge Province, Mongolia. The Korean journal of parasitology 52, 443-447. | |
| dcterms.references | Hongo, I., Bloch, K.C., 2006. Ehrlichia infection of the central nervous system. Current treatment options in neurology 8, 179-184. | |
| dcterms.references | Hunfeld, K.P., Hildebrandt, A., Gray, J.S., 2008. Babesiosis: recent insights into an ancient disease. International journal for parasitology 38, 1219-1237. | |
| dcterms.references | Ismail, N., Bloch, K.C., McBride, J.W., 2010. Human ehrlichiosis and anaplasmosis. Clinics in laboratory medicine 30, 261-292. | |
| dcterms.references | Kavanaugh, M.J., Decker, C.F., 2012. Babesiosis. Disease-a-month : DM 58, 355- 360. | |
| dcterms.references | Klein, M.B., Nelson, C.M., Goodman, J.L., 1997. Antibiotic susceptibility of the newly cultivated agent of human granulocytic ehrlichiosis: promising activity of quinolones and rifamycins. Antimicrob Agents Chemother 41, 76-79. | |
| dcterms.references | Krause, P.J., 2002. Babesiosis. The Medical clinics of North America 86, 361-373. | |
| dcterms.references | Krause, P.J., Daily, J., Telford, S.R., Vannier, E., Lantos, P., Spielman, A., 2007. Shared features in the pathobiology of babesiosis and malaria. Trends in parasitology 23, 605-610. | |
| dcterms.references | Labruna, M.B., McBride, J.W., Camargo, L.M., Aguiar, D.M., Yabsley, M.J., Davidson, W.R., Stromdahl, E.Y., Williamson, P.C., Stich, R.W., Long, S.W., Camargo, E.P., Walker, D.H., 2007. A preliminary investigation of Ehrlichia species in ticks, humans, dogs, and capybaras from Brazil. Veterinary parasitology 143, 189-195. | |
| dcterms.references | Leiby, D.A., 2006. Babesiosis and blood transfusion: flying under the radar. Vox sanguinis 90, 157-165. | |
| dcterms.references | Lin, M., Rikihisa, Y., 2003. Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival. Infection and immunity 71, 5324-5331. | |
| dcterms.references | Lin, M., Rikihisa, Y., 2004. Ehrlichia chaffeensis downregulates surface Toll-like receptors 2/4, CD14 and transcription factors PU.1 and inhibits lipopolysaccharide activation of NF-kappa B, ERK 1/2 and p38 MAPK in host monocytes. Cellular microbiology 6, 175-186. | |
| dcterms.references | Lockhart, J.M., Davidson, W.R., Dawson, J.E., Stallknecht, D.E., 1995. Temporal association of Amblyomma americanum with the presence of Ehrlichia chaffeensis reactive antibodies in white-tailed deer. Journal of wildlife diseases 31, 119-124. | |
| dcterms.references | Maeda, K., Markowitz, N., Hawley, R.C., Ristic, M., Cox, D., McDade, J.E., 1987. Human infection with Ehrlichia canis, a leukocytic rickettsia. The New England journal of medicine 316, 853-856. | |
| dcterms.references | Marshall, G.S., Jacobs, R.F., Schutze, G.E., Paxton, H., Buckingham, S.C., DeVincenzo, J.P., Jackson, M.A., San Joaquin, V.H., Standaert, S.M., Woods, C.R., Tick-Borne Infections in Children Study, G., 2002. Ehrlichia chaffeensis seroprevalence among children in the southeast and south- central regions of the United States. Archives of pediatrics & adolescent medicine 156, 166-170. | |
| dcterms.references | Martínez Abreu, J., 2014. Las enfermedades infecciosas emergentes y reemergentes, un tema de interés para todos. Revista Médica Electrónica 36, 537-539 | |
| dcterms.references | Marty, A.M., Dumler, J.S., Imes, G., Brusman, H.P., Smrkovski, L.L., Frisman, D.M., 1995. Ehrlichiosis mimicking thrombotic thrombocytopenic purpura. Case report and pathological correlation. Human pathology 26, 920-925. | |
| dcterms.references | Mattner, J., Debord, K.L., Ismail, N., Goff, R.D., Cantu, C., 3rd, Zhou, D., Saint- Mezard, P., Wang, V., Gao, Y., Yin, N., Hoebe, K., Schneewind, O., Walker, D., Beutler, B., Teyton, L., Savage, P.B., Bendelac, A., 2005. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434, 525-529. | |
| dcterms.references | Miranda, J., Mattar, S., 2013. Anaplasma sp y Ehrlichia sp. en garrapatas de bovinos, equinos y caninos del área tropical de Córdoba, Colombia. Acta Med Costarric 1, 69. | |
| dcterms.references | Monsalve, S., Mattar, S., Gonzalez, M., 2009. Zoonosis transmitidas por animales silvestres y su impacto en las enfermedades emergentes y reemergentes. Revista MVZ Córdoba 14. | |
| dcterms.references | Montes-Farah, J., De la Vega-Del Risco, F., Bello-Espinosa, A., 2012. Coinfección de babesiosis y ehrlichiosis: un caso en Cartagena de Indias, Colombia*. Revista Ciencias Biomedicas 3, 339-345. | |
| dcterms.references | Murphy, G.L., Ewing, S.A., Whitworth, L.C., Fox, J.C., Kocan, A.A., 1998. A molecular and serologic survey of Ehrlichia canis, E. chaffeensis, and E. ewingii in dogs and ticks from Oklahoma. Veterinary parasitology 79, 325- 339. | |
| dcterms.references | Mylonakis, M., Hatzis, A., Μυλωνάκης, Μ., Χατζής, Α., 2014. Practical bone marrow cytology in the dog and cat. JOURNAL OF THE HELLENIC VETERINARY MEDICAL SOCIETY 65, 181-196. | |
| dcterms.references | Nadelman, R.B., Horowitz, H.W., Hsieh, T.C., Wu, J.M., Aguero-Rosenfeld, M.E., Schwartz, I., Nowakowski, J., Varde, S., Wormser, G.P., 1997. Simultaneous human granulocytic ehrlichiosis and Lyme borreliosis. The New England journal of medicine 337, 27-30. | |
| dcterms.references | Ngo, V., Civen, R., 2009. Babesiosis acquired through blood transfusion, California, USA. Emerging infectious diseases 15, 785-787 | |
| dcterms.references | Olano, J.P., Hogrefe, W., Seaton, B., Walker, D.H., 2003a. Clinical manifestations, epidemiology, and laboratory diagnosis of human monocytotropic ehrlichiosis in a commercial laboratory setting. Clinical and diagnostic laboratory immunology 10, 891-896. | |
| dcterms.references | Olano, J.P., Masters, E., Hogrefe, W., Walker, D.H., 2003b. Human monocytotropic ehrlichiosis, Missouri. Emerging infectious diseases 9, 1579- 1586. | |
| dcterms.references | Openshaw, J.J., Swerdlow, D.L., 2007. Human ehrlichiosis: Clinical and ecological challenges. SOUTHERN MEDICAL JOURNAL-BIRMINGHAM ALABAMA- 100, 769. | |
| dcterms.references | Oteo, J.A., Brouqui, P., 2005. Ehrlichiosis y anaplasmosis humana. Enfermedades infecciosas y microbiologia clinica 23, 375-380. | |
| dcterms.references | Paddock, C.D., Childs, J.E., 2003a. Ehrlichia chaffeensis: a prototypical emerging pathogen. Clinical microbiology reviews 16, 37-64. | |
| dcterms.references | Paddock, C.D., Childs, J.E., 2003b. Ehrlichia chaffeensis: a prototypical emerging pathogen. Clinical microbiology reviews 16, 37-64. | |
| dcterms.references | Paddock, C.D., Suchard, D.P., Grumbach, K.L., Hadley, W.K., Kerschmann, R.L., Abbey, N.W., Dawson, J.E., Anderson, B.E., Sims, K.G., Dumler, J.S., et al., 1993. Brief report: fatal seronegative ehrlichiosis in a patient with HIV infection. The New England journal of medicine 329, 1164-1167. | |
| dcterms.references | Paddock, C.D., Sumner, J.W., Shore, G.M., Bartley, D.C., Elie, R.C., McQuade, J.G., Martin, C.R., Goldsmith, C.S., Childs, J.E., 1997. Isolation and characterization of Ehrlichia chaffeensis strains from patients with fatal ehrlichiosis. Journal of clinical microbiology 35, 2496-2502. | |
| dcterms.references | Parola, P., Davoust, B., Raoult, D., 2005a. Tick- and flea-borne rickettsial emerging zoonoses. Veterinary research 36, 469-492. | |
| dcterms.references | Parola, P., Raoult, D., 2001a. Tick-borne bacterial diseases emerging in Europe. Clinical microbiology and infection 7, 80-83. | |
| dcterms.references | Parola, P., Raoult, D., 2001b. Ticks and tickborne bacterial diseases in humans: an emerging infectious threat. Clinical infectious diseases 32, 897-928. | |
| dcterms.references | Perez, M., Bodor, M., Zhang, C., Xiong, Q., Rikihisa, Y., 2006. Human infection with Ehrlichia canis accompanied by clinical signs in Venezuela. Annals of the New York Academy of Sciences 1078, 110-117. | |
| dcterms.references | Persing, D.H., Mathiesen, D., Marshall, W.F., Telford, S.R., Spielman, A., Thomford, J.W., Conrad, P.A., 1992. Detection of Babesia microti by polymerase chain reaction. Journal of clinical microbiology 30, 2097-2103. | |
| dcterms.references | Peters, T.R., Edwards, K.M., Standaert, S.M., 2000. Severe ehrlichiosis in an adolescent taking trimethoprim- ulfamethoxazole. The Pediatric infectious disease journal 19, 170-172. | |
| dcterms.references | Popov, V.L., Chen, S.M., Feng, H.M., Walker, D.H., 1995. Ultrastructural variation of cultured Ehrlichia chaffeensis. Journal of medical microbiology 43, 411- 421. | |
| dcterms.references | Pretzman, C., Ralph, D., Stothard, D.R., Fuerst, P.A., Rikihisa, Y., 1995. 16S rRNA gene sequence of Neorickettsia helminthoeca and its phylogenetic alignment with members of the genus Ehrlichia. International journal of systematic bacteriology 45, 207-211. | |
| dcterms.references | Ratnasamy, N., Everett, E.D., Roland, W.E., McDonald, G., Caldwell, C.W., 1996. Central nervous system manifestations of human ehrlichiosis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 23, 314-319. | |
| dcterms.references | Reperant, L.A., 2010. Applying the theory of island biogeography to emerging pathogens: toward predicting the sources of future emerging zoonotic and vector-borne diseases. Vector borne and zoonotic diseases 10, 105-110. | |
| dcterms.references | Rikihisa, Y., 1999. Clinical and biological aspects of infection caused by Ehrlichia chaffeensis. Microbes and infection / Institut Pasteur 1, 367-376. | |
| dcterms.references | Rikihisa, Y., 2006. Ehrlichia subversion of host innate responses. Curr Opin Microbiol 9, 95-101. | |
| dcterms.references | Ríos, R., Franco, S., Mattar, S., Urrea, M., Tique, V., 2011. Seroprevalencia de Leptospira sp., Rickettsia sp. y Ehrlichia sp. en trabajadores rurales del departamento de Sucre, Colombia. Infectio 12. | |
| dcterms.references | Rodak, B.F., 2005. Hematología: fundamentos y aplicaciones clínicas. Ed. Médica Panamericana. | |
| dcterms.references | Rojas, N., Castillo, D., Marin, P., 2015. Molecular Detection of Ehrlichia chaffeensis in Humans, Costa Rica. Emerging infectious diseases 21, 532. | |
| dcterms.references | Sambri, V., Marangoni, A., Storni, E., Cavrini, F., Moroni, A., Sparacino, M., Cevenini, R., 2004. [Tick borne zoonosis: selected clinical and diagnostic aspects]. Parassitologia 46, 109-113. | |
| dcterms.references | Sasiaín, J.P., 2003. Cien años del colorante de Giemsa. Biomédica 23, 5-18. | |
| dcterms.references | Schotthoefer, A.M., Meece, J.K., Ivacic, L.C., Bertz, P.D., Zhang, K., Weiler, T., Uphoff, T.S., Fritsche, T.R., 2013. Comparison of a real-time PCR method with serology and blood smear analysis for diagnosis of human anaplasmosis: importance of infection time course for optimal test utilization. Journal of clinical microbiology 51, 2147-2153. | |
| dcterms.references | Schutze, G.E., Buckingham, S.C., Marshall, G.S., Woods, C.R., Jackson, M.A., Patterson, L.E., Jacobs, R.F., Tick-borne Infections in Children Study, G., 2007. Human monocytic ehrlichiosis in children. The Pediatric infectious disease journal 26, 475-479. | |
| dcterms.references | Schwint, O.N., Ueti, M.W., Palmer, G.H., Kappmeyer, L.S., Hines, M.T., Cordes, R.T., Knowles, D.P., Scoles, G.A., 2009. Imidocarb dipropionate clears persistent Babesia caballi infection with elimination of transmission potential. Antimicrob Agents Chemother 53, 4327-4332. | |
| dcterms.references | Sehdev, A.E., Dumler, J.S., 2003. Hepatic pathology in human monocytic ehrlichiosis. Ehrlichia chaffeensis infection. American journal of clinical pathology 119, 859-865. | |
| dcterms.references | Sexton, D.J., Corey, G.R., Carpenter, C., Kong, L.Q., Gandhi, T., Breitschwerdt, E., Hegarty, B., Chen, S.M., Feng, H.M., Yu, X.J., Olano, J., Walker, D.H., Dumler, S.J., 1998. Dual infection with Ehrlichia chaffeensis and a spotted fever group rickettsia: a case report. Emerging infectious diseases 4, 311- 316. | |
| dcterms.references | St. Clair, K., Decker, C.F., 2012. Ehrlichioses: Anaplasmosis and Human Ehrlichiosis. Disease-a-month : DM 58, 346-354. | |
| dcterms.references | Standaert, S.M., Yu, T., Scott, M.A., Childs, J.E., Paddock, C.D., Nicholson, W.L., Singleton, J., Jr., Blaser, M.J., 2000. Primary isolation of Ehrlichia chaffeensis from patients with febrile illnesses: clinical and molecular characteristics. The Journal of infectious diseases 181, 1082-1088 | |
| dcterms.references | Sumner, J.W., Childs, J.E., Paddock, C.D., 1999. Molecular cloning and characterization of the Ehrlichia chaffeensis variable-length PCR target: an antigen-expressing gene that exhibits interstrain variation. Journal of clinical microbiology 37, 1447-1453. | |
| dcterms.references | Sumner, J.W., Nicholson, W.L., Massung, R.F., 1997. PCR amplification and comparison of nucleotide sequences from the groESL heat shock operon of Ehrlichia species. Journal of clinical microbiology 35, 2087-2092. | |
| dcterms.references | Swanson, S.J., Neitzel, D., Reed, K.D., Belongia, E.A., 2006. Coinfections acquired from ixodes ticks. Clinical microbiology reviews 19, 708-727 | |
| dcterms.references | Tan, H.P., Dumler, J.S., Maley, W.R., Klein, A.S., Burdick, J.F., Fred Poordad, F., Thuluvath, P.J., Markowitz, J.S., 2001. Human monocytic ehrlichiosis: an emerging pathogen in transplantation. Transplantation 71, 1678-1680 | |
| dcterms.references | Taylor, L.H., Latham, S.M., Woolhouse, M.E., 2001. Risk factors for human disease emergence. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 356, 983-989. | |
| dcterms.references | Teal, A.E., Habura, A., Ennis, J., Keithly, J.S., Madison-Antenucci, S., 2012. A new real-time PCR assay for improved detection of the parasite Babesia microti. Journal of clinical microbiology 50, 903-908. | |
| dcterms.references | Thomas, L.D., Hongo, I., Bloch, K.C., Tang, Y.W., Dummer, S., 2007. Human ehrlichiosis in transplant recipients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 7, 1641-1647. | |
| dcterms.references | Vannier, E., Gewurz, B.E., Krause, P.J., 2008. Human babesiosis. Infectious disease clinics of North America 22, 469-488, viii-ix. | |
| dcterms.references | Vannier, E., Krause, P.J., 2012. Human babesiosis. The New England journal of medicine 366, 2397-2407. | |
| dcterms.references | Walker, D.H., Dumler, J.S., 1997. Human monocytic and granulocytic ehrlichioses. Discovery and diagnosis of emerging tick-borne infections and the critical role of the pathologist. Archives of pathology & laboratory medicine 121, 785-791. | |
| dcterms.references | Walls, J.J., Greig, B., Neitzel, D.F., Dumler, J.S., 1997. Natural infection of small mammal species in Minnesota with the agent of human granulocytic ehrlichiosis. Journal of clinical microbiology 35, 853-855. | |
| dcterms.references | White, D.J., Talarico, J., Chang, H.G., Birkhead, G.S., Heimberger, T., Morse, D.L., 1998. Human babesiosis in New York State: Review of 139 hospitalized cases and analysis of prognostic factors. Archives of internal medicine 158, 2149-2154. | |
| dcterms.references | Wormser, G.P., Dattwyler, R.J., Shapiro, E.D., Halperin, J.J., Steere, A.C., Klempner, M.S., Krause, P.J., Bakken, J.S., Strle, F., Stanek, G., Bockenstedt, L., Fish, D., Dumler, J.S., Nadelman, R.B., 2006. The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 43, 1089-1134. | |
| dcterms.references | Xiong, Q., Lin, M., Rikihisa, Y., 2009. Cholesterol-dependent anaplasma phagocytophilum exploits the low-density lipoprotein uptake pathway. PLoS pathogens 5, e1000329. | |
| dcterms.references | Yabsley, M.J., Shock, B.C., 2013. Natural history of Zoonotic Babesia: Role of wildlife reservoirs. International journal for parasitology. Parasites and wildlife 2, 18-31. | |
| dcterms.references | Yevich, S.J., Sanchez, J.L., DeFraites, R.F., Rives, C.C., Dawson, J.E., Uhaa, I.J., Johnson, B.J., Fishbein, D.B., 1995. Seroepidemiology of infections due to spotted fever group rickettsiae and Ehrlichia species in military personnel exposed in areas of the United States where such infections are endemic. The Journal of infectious diseases 171, 1266-1273. | |
| dcterms.references | Yoshiie, K., Kim, H.Y., Mott, J., Rikihisa, Y., 2000. Intracellular infection by the human granulocytic ehrlichiosis agent inhibits human neutrophil apoptosis. Infection and immunity 68, 1125-1133. | |
| dcterms.references | Zhang, J.Z., Popov, V.L., Gao, S., Walker, D.H., Yu, X.J., 2007. The developmental cycle of Ehrlichia chaffeensis in vertebrate cells. Cellular microbiology 9, 610-618. | |
| dcterms.references | Zhang, J.Z., Sinha, M., Luxon, B.A., Yu, X.J., 2004. Survival strategy of obligately intracellular Ehrlichia chaffeensis: novel modulation of immune response and host cell cycles. Infection and immunity 72, 498-507. | |
| dcterms.references | Zhang, L., Wang, G., Liu, Q., Chen, C., Li, J., Long, B., Yu, H., Zhang, Z., He, J., Qu, Z., Yu, J., Liu, Y., Dong, T., Yao, N., Wang, Y., Cheng, X., Xu, J., 2013. Molecular analysis of Anaplasma phagocytophilum isolated from patients with febrile diseases of unknown etiology in China. PloS one 8, e57155. | |
| dcterms.references | Zintl, A., Mulcahy, G., Skerrett, H.E., Taylor, S.M., Gray, J.S., 2003. Babesia divergens, a bovine blood parasite of veterinary and zoonotic importance. Clinical microbiology reviews 16, 622-636. | |
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