| dc.contributor.advisor | Arroyo Salgado, Bárbara Julia (Director/a) | |
| dc.contributor.author | Lozano Pineda, Juan Carlos | |
| dc.date.accessioned | 2021-03-26T16:44:43Z | |
| dc.date.available | 2021-03-26T16:44:43Z | |
| dc.date.issued | 2020 | |
| dc.description | Tesis (Magíster en Toxicología) -- Universidad de Cartagena. Facultad de Medicina. Departamento de Toxicología. Maestría en toxicología, 2020 | es |
| dc.description.abstract | Tópicos para la alopecia androgénica son comúnmente utilizados para tratamientos estéticos, donde los residuos de estos mismos son vertidos por desagües sin ningún tipo de tratamiento previo, sin considerar los efectos adversos que esto pueda generar sobre el ambiente marino y terrestre al acumularse en fuentes hídricas, hogar de muchas especies de plantas y animales. El objetivo de este trabajo fue evaluar los efectos de tres tópicos diferentes para alopecia androgénica que contienen minoxidil, sobre el modelo biológico de Caenorhabditis elegans. Para ello se expusieron los nematodos C. elegans a diferentes concentraciones con los tópicos (0,01; 0,1; 1; y 10 ppm) y se evaluaron los puntos finales de mortalidad, crecimiento, reproducción, acumulación lipídica y genes relacionados con estrés oxidativo y shock térmico (sod-4, gpx-4, gpx-6, hsp-3). Los resultados mostraron mayores efectos adversos en las concentraciones más altas (1 y 10 ppm), al causar los porcentajes más altos de mortalidad y reducción de la longitud corporal, principalmente en aquellos gusanos expuestos al tópico 3. El estrés oxidativo fue más evidente en los tópicos que presentaron menos aditivos, mostrando sobreexpresión principalmente en los genes sod-4 y gpx-6. Además, la acumulación lipídica fue notoria principalmente en las concentraciones 0,01 y 0,1 ppm. Sin embargo, en todos los tratamientos se observó acumulación lipídica. Lo anterior indica que los tópicos para alopecia androgénica con presencia de minoxidil afectan la vitalidad del nematodo alterando funciones como el crecimiento y el metabolismo de lípidos, además actúan con agentes estresores al causar sobre expresión de genes reguladores de estrés oxidativo. La descarga de estos tópicos al ambiente puede generar un impacto negativo sobre los ecosistemas al afectar la vitalidad de seres vivos como C. elegans. | es |
| dc.format.medium | application/pdf | es |
| dc.identifier.citation | TM615.908 / L959 | es |
| dc.identifier.uri | https://hdl.handle.net/11227/11672 | |
| dc.identifier.uri | http://dx.doi.org/10.57799/11227/2093 | |
| dc.language.iso | spa | es |
| dc.publisher | Universidad de Cartagena | es |
| dc.rights.access | openAccess | es |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0 | es |
| dc.subject | Toxicología - Investigaciones | es |
| dc.subject | Estrés oxidativo - Investigaciones | es |
| dc.subject | Alopecia androgénica | es |
| dc.subject | Alopecia - Tratamiento | es |
| dc.subject | Minoxidil - Efectos toxicológicos | es |
| dc.title | Evaluación del efecto toxicológico adverso de tópicos para la alopecia androgénica utilizando un modelo biológico de caenorhabditis elegans | es |
| dc.type | Trabajo de grado - Maestría | spa |
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| dspace.entity.type | Publication |
Sede: Claustro de San Agustín, Centro Histórico, Calle de la Universidad Cra. 6 #36-100
Colombia, Bolívar, Cartagena
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