Farmacia asistencial

URI permanente para esta colecciónhttps://hdl.handle.net/11227/17706

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  • Miniatura
    PublicaciónAcceso abierto
    Stratification of cephalosporins based on physicochemical and pharmacokinetic variables using multivariate statistical tools.
    (Universidad de Cartagena., 2024) Carlos Alberto Escobar Angulo
    Prescription is one of the most important strategies for the treatment of patients, with the objective of managing symptoms and, on occasion, preventing future conditions. Prescribing is a complex exercise that requires diagnostic skills, knowledge of common medications, understanding of the principles of clinical pharmacology, communication skills, and the ability to make decisions based on judgments of potential benefits and risks based on available evidence and specific factors related to the patient being treated. The progressive accumulation of clinical trial data on commonly used drugs would allow the possibility of providing sufficient evidence to support most prescribing decisions. Journal Pre-proof However, physicians generally prescribe under varying circumstances and often in the absence of directly related evidence. Rational prescribing decisions are often based on evidence that must be interpreted in the context of many other factors not found in any clinical trial. (1–4). Considering that the most widely used therapeutic technology is the drug, but in some circumstances, its use can be inefficient, which affects the quality of healthcare, jeopardizes patient safety, and wastes resources. Clinicians are confronted with an everincreasing supply of drugs that exceeds their knowledge of how to use them; therefore, it is necessary to select drugs rationally, based on evidence of efficacy and safety, while seeking the greatest benefit for patients at the lowest possible cost. Medicines can be selected at different levels: health systems, organizations, health centers, and professionals, but they always follow the same criteria. As the drug and its knowledge are constantly changing, drug evaluation and selection must be a continuous and multidisciplinary process. Due to those above, it is pertinent to propose strategies based on multivariate statistical tools, taking into account the capacity of this type of statistics to stratify the different pharmacological alternatives in order to provide less subjective options to the prescribing team. (5,6) A group of drugs frequently used in clinical practice are cephalosporins, which correspond to a type of beta-lactam antibiotics frequently used in medicine due to their high activity against bacteria, proven efficacy, and good safety. These antimicrobials are used as first-choice treatments in various clinical conditions, such as skin and soft tissue infections, intra-abdominal sepsis, diabetic foot infections, acute meningitis, pneumonia, endocarditis, and as prophylaxis in cardiothoracic, orthopedic, abdominal and pelvic surgery. However, they can be used indistinctly without taking into account some possible advantages derived from their physicochemical and pharmacokinetic variables, a situation that, at a given moment, may allow better diffusion to infected tissues. The objective was to look for options to interpret and take advantage of the information related to the physicochemical nature of drugs in order to facilitate decision-making on the choice of pharmacological therapies, trying to select the appropriate alternatives for each case based on their possible kinetics and distribution on the basis of the inherent properties of each substance. (7)
  • Miniatura
    PublicaciónAcceso abierto
    Resultados de la evaluación individual del riesgo farmacológico de pacientes de atención domiciliaria haciendo uso del método Deti de atención farmacéutica.
    (Universidad de Cartagena., 2024) Ávila Padilla, Manuel de los Santos; Alvis Amador, Antistio Aníbal
    Este proyecto tiene como objeto evaluar el riesgo farmacológico Individual de los pacientes del servicio de atención domiciliaria de una entidad de régimen especial en la ciudad de Cartagena de Indias durante los meses de enero a julio de 2023, haciendo uso del método DETI de atención farmacéutica. El estudio pone de manifiesto la importancia de contar con una metodología eficiente para la atención farmacéutica que haga uso de escalas validadas con el fin optimizar la labor del Químico farmacéutico asistencial. Por otro lado, pone de manifiesto que, en la población de estudio, el Riesgo farmacológico al que se expone un paciente según la EEIRF es evidente por las variables medidas y según su cuantificación, el 95% de ellos requieren atención Farmacéutica y Seguimiento Farmacoterapéutico Cada 2, 3 o 6 Meses o antes según condición clínica por su muy alta probabilidad de presentar situaciones Adversas o Problemas de Salud asociados con el uso de los Medicamentos que recibe.
  • Miniatura
    PublicaciónAcceso abierto
    Individual assessment of pharmacological risk in patients receiving home care services in the Cartagena city
    (Universidad de Cartagena, 2024) Chávez Mora, Dinohora Judith; Alviz Amador, Antistio A.; Avila P, Manuel de Los Santos
    Currently there are scales or strategies that evaluate some risks associated with the use of medications in specific population groups, but they do not consider some important variables that are found during pharmaceutical care. The Individual Pharmacological Risk Evaluation Scale (EEIRF) that is used during the application of the DETI Method of Pharmaceutical care is an efficient tool to know the Individual Pharmacological Risk of a patient, facilitating its comprehensive approach and the generation of strategies for the team of care and the patient. METHOD: A descriptive, longitudinal, prospective study was carried out that included patients from the Home Care program. For the Individual Evaluation of the Pharmacological Risk of the patients, the DETI method of Pharmaceutical Care and Pharmacotherapeutic Follow-up and its EEIRF were applied. RESULTS: The clinical and environmental conditions were identified that allowed defining the probability that a patient would present Adverse situations or Health Problems associated with their use of the Medications they received and it was found that 22% of the patients were exposed to a Very High Pharmacological Risk. High, 27% at High risk, 46% at Moderate risk and 5% at Low risk. CONCLUSION: In the study population, the pharmacological risk to which a patient is exposed according to the EEIRF is evident by the variables measured and according to its quantification, 95% of them require Pharmaceutical attention and Pharmacotherapeutic Follow-up Every 2, 3 or 6 Months or sooner depending on condition clinic due to its VERY HIGH, HIGH and MODERATE PROBABILITY of presenting Adverse situations or Health Problems associated with the use of the Medications you receive.

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