Blog Grupo de Investigacion Salud de la Mujer

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Browsing Blog Grupo de Investigacion Salud de la Mujer by Author "Calle, Andrès"

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    Association between type of menopause and mild cognitive impairment: The REDLINC XII study
    (Elsevier, 2024-11) Espinoza, María T.; Blümel, Juan E; Chedraui, Peter; Vallejo, María S.; Ñañez, Monica; Ojeda, Eliana; Rey, Claudia; Rodríguez, Doris; Rodrigues, Marcio A.; Salinas, Carlos; Tserotas, Konstantinos; Calle, Andrès; Dextre, Maribel; Elizalde, Alejandra; Escalante, Carlos; Gomez-Tabares, Gustavo; Monterrosa-Castro, Àlvaro; Grupo de investigacion Salud de la Mujer
    Objective: To evaluate the association between type of menopause (spontaneous or surgical) and mild cognitive impairment (MCI). Study design: This study was a cross-sectional, observational, and sub-analytical investigation conducted within gynecological consultations across nine Latin American countries. Method: We assessed sociodemographic, clinical, and anthropometric data, family history of dementia, and the presence of MCI using the Montreal Cognitive Assessment (MoCA) tool. Results: The study involved 1185 postmenopausal women with a mean age of 55.3 years and a body mass index of 26.4 kg/m2 . They had an average of 13.3 years of education, and 37 % were homemakers. Three hundred ninetynine experienced menopause before 40, including 136 with surgical menopause (bilateral oophorectomy). Out of the 786 women who experienced menopause at 40 or more years, 110 did so due to bilateral oophorectomy. There were no differences in MoCA scores among women who experienced menopause before or after the age of 40. However, lower MoCA scores were observed in women with surgical menopause than in those with spontaneous menopause (23.8 ± 4.9 vs. 25.0 ± 4.3 points, respectively, p < 0.001). Our logistic regression model with clustering of patients within countries found a significant association between MCI and surgical menopause (OR 1.47, 95 % CI: 1.01–2.16), use (ever) of menopausal hormone therapy (OR 0.33, 95 % CI: 0.21–0.50), and having >12 years of education (OR 0.21, 95 % CI: 0.14–0.30). Conclusion: When comparing women who experience spontaneous menopause over the age of 40 with those who undergo it before this age, there was no observed increased risk of developing MCI, while those with surgical
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    Risk of sarcopenia: A red flag for cognitive decline in postmenopause
    (Elsevier, 2025-03) Vallejo, María S.; Blümel, Juan E.; Tserotas, Konstantinos; Salinas, Carlos; Rodrigues, Marcio A.; Rodríguez-Vidal, Doris; Rey, Claudia; Ojeda, Eliana; Ñañez, Monica; Monterrosa-Castro, Àlvaro; Gomez-Tabares, Gustavo; Espinoza, María T.; Escalante, Carlos; Elizalde, Alejandra; Dextre, Maribel; Calle, Andrès; Aedo, Sòcrates; Grupo de investigacion Salud de la Mujer
    Objective: To determine if the SARC-F tool, used to screen for sarcopenia risk, can also predict mild cognitive impairment (MCI) diagnosed with the Montreal Cognitive Assessment (MoCA) tool. Methods: This is a sub-analysis of data from a cross-sectional study carried out in postmenopausal women from Latin America (nine countries) in which sociodemographic, clinical, and anthropometric data were collected, and the SARC-F and MoCA tools administered. From the original sample of 1185 women, analysis was performed only among the 772 with natural menopause. Results: Overall, mean age, body mass index and years of education were 56.9 years, 26.8 kg/m2 and 13.6 years, respectively. Women with MCI displayed a higher body mass index, had more children, experienced more severe menopausal symptoms, and were more frequently homemakers and physically inactive. The prevalence of MCI increased from 12.9 % in women with no sarcopenia risk (SARC-F < 4 points) to 35.3 % in those at risk (OR 3.70; 95 % CI 2.36–5.80). According to binary logistic regression analysis, sarcopenia risk (total SARC-F score ≥ 4) was associated with MCI (OR: 2.44; 95 % CI 1.50–3.95). Aside from the risk of sarcopenia, being a homemaker (OR 1.97; 95 % CI 1.25–3.10) was also associated with an increased likelihood of MCI. Protective factors included ever use of menopausal hormone therapy (OR 0.26; 95 % CI 0.13–0.54) and having higher educational attainment (OR 0.28; 95 % CI 95 % 0.16–0.47). The SARC-F displayed a sensitivity of 84 % and a specificity of 39 % at diagnosing MCI.

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