Publicación:

Endocrine disruptors as ligands of breast cancer proteins

Resumen

Thesis was to evaluate the plausibility of EDCs to bind breast cancer proteins, through a three-steps approach: creation of a database of EDCs with three-dimensional structure available, an inverse virtual screening of bisphenol A (BPA) -one of the xenoestrogens to which we are most frequently exposed to- against proteins involved in different signaling pathways, and a virtual high-throughput screening (vHTS) among EDCs and proteins involved in this disease with an evaluation of the interactions of a protein-ligand complex through spectroscopic methods.