Publication:

Natural bioactive compounds as inhibitors of cáncer targets

Abstract

In this thesis are presented the results of a multidisciplinary methodological strategy that included powerful computational tools such as molecular docking (AutoDock vina, GOLD and Surflex-Dock, SYBYL), pharmocophoremapping (Ligand Scout 3.0) combined with statistical methods (cluster analisis, lincar discriminant analysis, linear regression, among others) to the search for natural compounds with anticancer activity by inhibition of cancer targets such as, COX-2, iNos and DNMT1.