Montes G., Diana2017-03-232017-03-232015TD616.99249 / M764https://hdl.handle.net/11227/4259http://dx.doi.org/10.57799/11227/153Tesis (Doctor en Toxicología Ambiental) - Universidad de Cartagena, Facultad de Ciencias Farmacéuticas. Programa de Toxicología Ambiental, 2015Thesis was to evaluate the plausibility of EDCs to bind breast cancer proteins, through a three-steps approach: creation of a database of EDCs with three-dimensional structure available, an inverse virtual screening of bisphenol A (BPA) -one of the xenoestrogens to which we are most frequently exposed to- against proteins involved in different signaling pathways, and a virtual high-throughput screening (vHTS) among EDCs and proteins involved in this disease with an evaluation of the interactions of a protein-ligand complex through spectroscopic methods.application/pdfenghttps://creativecommons.org/licenses/by-nc-nd/4.0EndocrinologíaMamas - TumoresTrabajo de grado - DoctoradoopenAccess