Monterrosa-Castro, ÁlvaroMonterrosa-Blanco, AngelicaSánchez-Zarza, Sandra2025-05-132025-05-132024-040951-3590https://hdl.handle.net/11227/19444Objective: To evaluate the association between subclinical hypothyroidism with early menopause, premature menopause, and last menstrual bleeding before the natural age of menopause. Methods: This was a cross-sectional study conducted in 643 postmenopausal women aged 40–69years. Groups were formed according to last menstrual episode: ≥45 [Natural age at menopause], 40–44 and [Early menopause], <40 [Premature menopause], and <45 [last menstrual episode before the natural age of menopause]. The Zulewski scale was applied to identify manifestations related to hypothyroidism and subclinical hypothyroidism, diagnosed with a serum TSH > 4.5 µIU/mL plus T4-free between 0.7 and 1.9ng/dL. Results: It was found that 24.4% had the last menstrual episode before the natural age of menopause, 18.6% had early menopause, and 5.7% had premature menopause. Subclinical hypothyroidism was diagnosed in 4.5% of patients. Among women with subclinical hypothyroidism, there was a higher frequency of early menopause, premature menopause, and last menstrual episode before the natural age of menopause, than in women without subclinical hypothyroidism (p<0.05). Paresthesia (50%) and dry skin (40.7%) were the most reported hypothyroidism-related manifestations. Early menopause, premature menopause, and last menstrual episode before the natural age of menopause were associated with subclinical hypothyroidism, OR: 3.37 [95% CI: 1.40–8.10], OR: 4.31 [95% CI: 1.24–14.97], and OR: 3.57 [95% CI: 1.57–8.10], respectively. Conclusions: The last menstrual episode before the natural age of menopause, early menopause, and premature menopause were significantly associated with a higher chance of subclinical hypothyroidismapplication/pdfenghttps://creativecommons.org/licenses/by-nc/4.0/Artículo de revistaAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)http://purl.org/coar/access_right/c_abf21473-0766info:eu-repo/semantics/openAccess3. Ciencias Médicas y de la SaludEdad de la menopausiaMenopausia tempranaMenopausiaMenopausia prematuraClimatéricoHipotiroidismoHormona estimulante de la tiroidesAge at menopauseEarly menopauseMenopausePremature menopauseClimactericHhypothyroidismThyroid-stimulating hormoneODS 3: Salud y bienestar. Garantizar una vida sana y promover el bienestar de todos a todas las edades