Calle, AndrésBlümel, Juan E.Chedraui, PeterVallejo, María S.Belardo, AlejandraDextre, MaribelElizalde-Cremonte, AlejandraEscalante, CarlosEspinoza, María T.Gómez-Tabares, GustavoMonterrosa-Castro, AlvaroÑañez, MónicaOjeda, ElianaRey, ClaudiaRodríguez, DorisRodrigues, Marcio A.Salinas, CarlosTserotas, KonstantinosAedo, Sócrates2025-05-062025-05-0620241530-0374https://hdl.handle.net/11227/19385Objective: To evaluate the association between menopausal symptoms and cognitive decline in postmenopausal women. Methods: This was a subanalysis of a cross-sectional, observational study conducted among women attending gynecological consultations across nine Latin American countries. The survey involved late postmenopausal women who were asked to complete a general questionnaire and the Menopause Rating Scale (MRS) to assess menopausal symptoms, with the Montreal Cognitive Assessment used to evaluate cognitive function as an outcome. A Montreal Cognitive Assessment score of less than 21 was used to define women with mild cognitive impairment (MCI). Results: The study included 1,287 postmenopausal women with a mean age of 55.5 years and a mean body mass index of 26.3 kg/m2 . On average, participants had 13.8 years of education and 2.3 ± 1.8 children, with 72.8% reporting having a partner. Additionally, 36.7% ever used menopausal hormone therapy. Regarding lifestyle factors, 50.3% engaged in a sedentary lifestyle, whereas 70.5% had never smoked. 15.3% of women had MCI exhibited significantly more intense menopausal symptoms compared with those without MCI (MRS total score 15.24 ± 12.58 vs 10.53 ± 8.84, respectively, P < 0.001). Logistic regression analysis revealed a significant association between severe menopausal symptoms (MRS total score ≥14 points) and MCI (odds ratio [OR], 1.74; 95% CI, 1.25-2.42). Conversely, a lower body mass index (OR, 0.96; 95% CI, 0.95-0.98), sexual activity (OR, 0.70; 95% CI, 0.51-0.96), physical exercise (OR, 0.55; 95% CI, 0.39-0.76), menopausal hormone therapy use (OR, 0.36; 95% CI, 0.24-0.55), and higher educational level (OR, 0.31; 95% CI, 0.21-0.46) were associated with lower odds for MCI. Conclusion: Severe menopausal symptoms in postmenopausal women were associated with cognitive impairment. This study highlights the intricate interplay between hormonal, lifestyle, and sociodemographic factors and cognitive health.application/pdfhttps://creativecommons.org/licenses/by-nc/4.0/Artículo de revistaAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)http://purl.org/coar/access_right/c_abf21530-0374info:eu-repo/semantics/openAccess3. Ciencias Médicas y de la SaludTerapia hormonal para la menopausiaSíntomas de la menopausiaEscala de evaluación de la menopausiaDeterioro cognitivo leveEvaluación cognitiva de MontrealMenopausal hormone therapyMenopause Rating ScaleMild cognitive impairmentMontreal Cognitive Assessment.ODS 3: Salud y bienestar. Garantizar una vida sana y promover el bienestar de todos a todas las edades