Maldonado Rojas, Wilson2017-06-012017-06-012016TD542.1 / M293https://hdl.handle.net/11227/4567http://dx.doi.org/10.57799/11227/151Thesis (Doctor in Environmental Toxicology). -- University cartagena. Faculty of Pharmaceutical Sciences. Environmental Toxicology Program, 2016In this thesis are presented the results of a multidisciplinary methodological strategy that included powerful computational tools such as molecular docking (AutoDock vina, GOLD and Surflex-Dock, SYBYL), pharmocophoremapping (Ligand Scout 3.0) combined with statistical methods (cluster analisis, lincar discriminant analysis, linear regression, among others) to the search for natural compounds with anticancer activity by inhibition of cancer targets such as, COX-2, iNos and DNMT1.application/pdfenghttps://creativecommons.org/licenses/by-nc-nd/4.0Pruebas de toxicidad in vitroCompuestos orgánicos - InvestigacionesBlancos molecularesCáncer - Inhibidores de proteasaTrabajo de grado - DoctoradoopenAccess