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Slide 1 of 6 Publicación Acceso abierto
Angiotensin-Converting Enzyme I/D Polymorphism and Preeclampsia Risk: evidence of small-study bias.
(Universidad de Cartagena., 2006) Norma C. Serrano; Luis A. DÍaz; Maria C. Páez; Clara M. Mesa; Rodrigo Cifuentes; Alvaro Monterrosa; Adriana González; Liam Smeeth; Aroon D. Hingorani; Juan P. Casas
Background
Inappropriate activation of the renin–angiotensin system may play a part in the development
of preeclampsia. An insertion/deletion polymorphism within the angiotensin-I converting
enzyme gene (ACE-I/D) has shown to be reliably associated with differences in angiotensinconverting enzyme (ACE) activity. However, previous studies of the ACE-I/D variant and
preeclampsia have been individually underpowered to detect plausible genotypic risks.
Methods and Findings
A prospective case-control study was conducted in 1,711 unrelated young pregnant women
(665 preeclamptic and 1,046 healthy pregnant controls) recruited from five Colombian cities.
Maternal blood was obtained to genotype for the ACE-I/D polymorphism. Crude and adjusted
odds ratio (OR) and 95% confidence interval (CI) using logistic regression models were obtained
to evaluate the strength of the association between ACE-I/D variant and preeclampsia risk. A
meta-analysis was then undertaken of all published studies to February 2006 evaluating the
ACE-I/D variant in preeclampsia. An additive model (per-D-allele) revealed a null association
between the ACE-I/D variant and preeclampsia risk (crude OR ¼ 0.95 [95% CI, 0.81–1.10]) in the
new case-control study. Similar results were obtained after adjusting for confounders (adjusted
per-allele OR¼0.90 [95% CI, 0.77–1.06]) and using other genetic models of inheritance. A metaanalysis (2,596 cases and 3,828 controls from 22 studies) showed a per-allele OR of 1.26 (95% CI,
1.07–1.49). An analysis stratified by study size showed an attenuated OR toward the null as
study size increased.
Conclusions
It is highly likely that the observed small nominal increase in risk of preeclampsia associated
with the ACE D-allele is due to small-study bias, similar to that observed in cardiovascular
disease. Reliable assessment of the origins of preeclampsia using a genetic approach may
require the establishment of a collaborating consortium to generate a dataset of adequate size.
Slide 2 of 6 Publicación Acceso abierto
Assessment of the frequency of sleep complaints and menopausal symptoms in climacteric women using the Jenkins Sleep Scale.
(Universidad de Cartagena., 2021) Alvaro Monterrosa Castro; Teresa Beltrán-Barrios; María Mercado-Lara
Objective: To identify the frequency of sleep complaints (SC) and associated menopausal symptoms
in climacteric women, apparently healthy, residing in three different capital cities of the Colombian
Caribbean. Material and Methods: Cross-sectional study which is part of the investigation project
CAVIMEC [Calidad de Vida en la Menopausia y Etnias Colombianas]. Data were collected by interviewers,
on a door-to-door visit. Healthy women residing in the Colombian Caribbean, 40-59 years old,
were studied. Sociodemographic characteristics form and scales were applied: Menopause Rating
Scale, Jenkins Sleep Scale, Perceived Psychological Stress (perceived stress), Goldberg Anxiety and
Depression Scale, SCOFF scale (eating disorders), and Loneliness Scale by Hughes. The women
were divided into two groups: with SC and without SC, according to the Jenkins scale result. Crude
and adjusted logistic regressions were performed: SC (dependent variable) with sociodemographic
characteristics and the results of the scales used (independent variables). Results: Five hundred
eighty-five women were studied. 16.5% with SC. No differences were observed in age, BMI, and
high blood pressure. Proportionally more women with SC had depression, anxiety, perception of
loneliness, severe menopausal symptoms, somatic, psychological, urogenital, and quality of life
severe impairment (p<0.05). There were no differences in eating disorders and perceived stress. In
the adjusted model, only depression was associated with SC, OR: 9.81 [95% CI: 1.29-74.3], p<0.05.
Conclusion: SC were identified in 16.5% of the climacteric women of the Colombian Caribbean.
In an adjusted model, probable depression was the only factor associated with SC.
Slide 3 of 6 Publicación Acceso abierto
Afectación de la calidad de vida generada por el vitiligo con compromiso genital en mujeres adultas residentes en el Caribe colombiano.
(Universidad de Cartagena., 2024) Álvaro Monterrosa-Castro; Isabel Torres-Castilla; Ana Castro-Caro
El vitíligo genital femenino afecta la piel de la vulva y puede cursar aislado o generalizado. Objetivo:
identificar la magnitud de la afectación de la calidad de vida (CV), sus consecuencias, la carga psicosocial y el impacto que
genera el vitiligo con compromiso genital. Método: se diseñó un estudio descriptivo con mujeres adultas con vitiligo genital
y residentes en el caribe colombiano. Se evaluó CV, sus consecuencias, carga psicosocial e impacto del vitiligo con
Dermatology Life Quality Index y Vitiligo Impact Scale. Resultados: participaron 78 mujeres, edad: 46,8±12,5. El 69,2% fue
“grande” o “extremadamente grande” en afectación de la CV y en el 79% a consecuencia de la limitación en las relaciones
interpersonales o en la sexualidad y en el 97,4% fue alto el impacto psicosocial en la afectación de la CV. Conclusiones: el
vitíligo genera alto impacto y gran magnitud en la afectación en la CV en mujeres.
Slide 4 of 6 Publicación Acceso abierto
Increased menopausal symptoms among Afro-Colombian Women as assessed with the menopause rating scale.
(Elsevier, 2008) Alvaro Monterrosa; Juan E. Blumel; Peter Chedraui
Increased frequency and severity of menopausal symptoms have been associated to black race. However, this
situation has not been described in any Latin American population.
Objective: Compare frequency and severity of menopausal symptoms among Afro and non-Afro Hispanic Colombian climacteric
women.
Methods: In this cross-sectional study, healthy Afro and non-Afro-Colombian women aged 40–59 years were asked
to fill out the Menopause Rating Scale (MRS) questionnaire in order to compare symptom frequency and intensity.
Results: A total of 578 women were surveyed (201 Afro-Colombian and 377 non-Afro-Colombian). Mean age of the whole
sample was 47.9 ± 5.9 years (median 47), with no differences among studied groups in terms of age, parity, and hormone
therapy (HT) use. Intensity of menopausal symptoms, assessed with the total MRS score, was found to be significantly higher
among Afro-Colombian women (10.6 ± 6.7 vs. 7.5 ± 5.7, p = 0.0001), which was due to higher somatic and psychological
subscale scores. In this group, the frequency of somatic symptoms, heart discomfort and muscle and joint problems, was
found to be higher than in non-Afro-Colombian women (38.8% vs. 26.8% and 77.1% vs. 43.5%, respectively, p < 0.05);
equally, all items of the psychological subscale (depressive mood, irritability, anxiety and physical exhaustion) were also
found to be higher among black women. On the other hand, compared to black women non-Afro-Colombian ones presented
more bladder problems (24.9% vs. 14.9%, p = 0.005). After adjusting for confounding factors, logistic regression analysis determined that black race increased the risk for presenting higher total MRS scorings (OR: 2.31; CI 95%: 1.55–3.45,
p = 0.0001).
Slide 5 of 6 Publicación Acceso abierto
Nivel de conocimientos sobre anticoncepción de emergencia en médicos generales que ejercen en Cartagena, Colombia.
(Universidad de Cartagena., 2002) Alvaro Monterrosa Castro; Dager Dumett Ruiz.; Luis Guillermo Anillo Osorio.; Irma Patricia Blanco Castillo.; Dairo Castilla Castro.; Fernando Gomez Simancas.
La anticoncepción de emergencia es una importante estrategia de regulación de la fertilidad,
para utilizar cuando se han tenido coitos sin protección y prevenir tanto el embarazo indeseado
como el subsiguiente aborto en condiciones de
riesgo. La anticoncepción de emergencia no es en
definitiva un método abortivo. Para generar la expansión de la anticoncepción de emergencia hacia
el acceso global, como sugiere el Consorcio sobre
Anticoncepción de Emergencia, debe el cuerpo
profesional de atención en salud sexual y
reproductiva, especialmente el medico general,
poseer claros y solidos conocimientos, los cuales
deben ser coherentes con su comprometimiento
comunitario.
Slide 6 of 6 Publicación Acceso abierto
IX Escuela internacional de Matemáticas del Caribe.
(Universidad de Cartagena., 2019) Hernandez Arzusa, Julio Cesar (compilador); Julio Cesar Hernandez Arzusa; Ana Magnolia MarÍn RamÍrez; Ruben Darıo Ortiz Ortiz; Sandra Gutierrez Meza
Este proyecto tiene como objeto destacar la importancia de los 30 años del Programa de Matemáticas. La Facultad de Ciencias Exactas y Naturales de la Universidad de Cartagena, organiza la IX Escuela Internacional de Matemáticas del Caribe, con el objetivo de fomentar en los estudiantes y en la comunidad académica en general, espacios donde se aborden temas de matemáticas y afines, mas alla de los tratados en las aulas de clases. Son precisamente estos eventos los resumidos en este libro y los que motivan a los estudiantes y profesores a seguir líneas de estudio, tanto para trabajo de grado, como investigaciones futuras. Al igual que en años anteriores, se presentaron profesores investigadores a nivel nacional e internacional, los que desarrollaron temas de Algebra, Topología, Estadística, Ecuaciones Diferenciales, Teoría de Grafos, Física, Geometría, Matemáticas Computacionales y Aplicadas.
